| Date | Location | Result | Record | ||
| June 2, 2018 | Austin, Texas | Indiana 6, Texas Southern 0 | 27-28 | Box score | |
| June 1, 2018 | Austin, Texas | Texas 10, Texas Southern 0 | 27-27 | Box score |
| Date | Location | Result | Record | ||
| May 20, 2018 | New Orleans, La. | Texas Southern 18, Grambling State 3 | 27-26 | Box score | |
| May 19, 2018 | New Orleans, La. | Texas Southern 10, Jackson State 9 | 26-26 | Box score | |
| May 17, 2018 | New Orleans, La. | Texas Southern 8, Jackson State 4 | 25-26 | Box score | |
| May 16, 2018 | New Orleans, La. | Texas Southern 10, Alcorn State 3 | 24-26 | Box score |
| Date | Location | Result | Record | (SWAC) | ||
| May 6, 2018 | * | Houston, Texas | Grambling State 7, Texas Southern 6 | 23-26 | (17-6) | Box score |
| May 5, 2018 | * | Houston, Texas | Texas Southern 11, Grambling State 3 | 23-25 | (17-5) | Box score |
| May 4, 2018 | * | Houston, Texas | Texas Southern 8, Grambling State 1 | 22-25 | (16-5) | Box score |
| May 2, 2018 | Corpus Christi, Texas | Texas A&M-Corpus Christi 7, Texas Southern 5 | 21-25 | Box score | ||
| April 29, 2018 | * | Pine Bluff, Ark. | Texas Southern 13, Arkansas-Pine Bluff 3 | 21-24 | (15-5) | Box score |
| April 28, 2018 | * | Pine Bluff, Ark. | Texas Southern 7, Arkansas-Pine Bluff 4 | 20-24 | (14-5) | Box score |
| April 27, 2018 | * | Pine Bluff, Ark. | Arkansas-Pine Bluff 6, Texas Southern 5 | 19-24 | (13-5) | Box score |
| April 24, 2018 | New Orleans, La. | Tulane 8, Texas Southern 2 | 19-23 | Box score | ||
| April 22, 2018 | * | Prairie View, Texas | Texas Southern 21, Prairie View A&M 1 | 19-22 | (13-4) | Box score |
| April 21, 2018 | * | Prairie View, Texas | Texas Southern 23, Prairie View A&M 0 | 18-22 | (12-4) | Box score |
| April 20, 2018 | * | Prairie View, Texas | Texas Southern 18, Prairie View A&M 11 | 17-22 | (11-4) | Box score |
| April 18, 2018 | Sugar Land, Texas | Texas 10, Texas Southern 2 | 16-22 | Box score | ||
| April 17, 2018 | Waco, Texas | Baylor 5, Texas Southern 4 | 16-21 | Box score | ||
| April 15, 2018 | * | Houston, Texas | Texas Southern 7, Southern 5 | 16-20 | (10-4) | Box score |
| April 14, 2018 | * | Houston, Texas | Texas Southern 4, Southern 0 | 15-20 | (9-4) | Box score |
| April 14, 2018 | * | Houston, Texas | Texas Southern 7, Southern 6 | 14-20 | (8-4) | Box score |
| April 10, 2018 | Houston, Texas | Texas Southern 12, Huston-Tillotson (Texas) 0 | 13-20 | Box score | ||
| April 10, 2018 | Houston, Texas | Texas Southern 4, Huston-Tillotson (Texas) 3 | 12-20 | Box score | ||
| April 8, 2018 | San Antonio, Texas | Incarnate Word 7, Texas Southern 4 | 11-20 | Box score | ||
| April 7, 2018 | San Antonio, Texas | Incarnate Word 10, Texas Southern 1 | 11-19 | Box score | ||
| April 6, 2018 | San Antonio, Texas | Texas Southern 9, Incarnate Word 8 | 11-18 | Box score | ||
| April 1, 2018 | * | Grambling, La. | Grambling State 9, Texas Southern 8 | 10-18 | (7-4) | Box score |
| March 31, 2018 | * | Grambling, La. | Texas Southern 18, Grambling State 7 | 10-17 | (7-3) | Box score |
| March 30, 2018 | * | Grambling, La. | Grambling State 10, Texas Southern 5 | 9-17 | (6-3) | Box score |
| March 27, 2018 | Nacogdoches, Texas | Stephen F. Austin 5, Texas Southern 4 | 9-16 | Box score | ||
| March 25, 2018 | * | Houston, Texas | Texas Southern 9, Arkansas–Pine Bluff 2 | 9-15 | (6-2) | Box score |
| March 24, 2018 | * | Houston, Texas | Texas Southern 10, Arkansas–Pine Bluff 0 | 8-15 | (5-2) | Box score |
| March 23, 2018 | * | Houston, Texas | Arkansas–Pine Bluff 12, Texas Southern 10 | 7-15 | (4-2) | Box score |
| March 21, 2018 | Starkville, Miss. | Mississippi State 11, Texas Southern 6 | 7-14 | Box score | ||
| March 20, 2018 | Houston, Texas | Texas Southern 3, Houston Baptist 2 | 7-13 | Box score | ||
| March 17, 2018 | * | Houston, Texas | Texas Southern 10, Prairie View A&M 0 | 6-13 | (4-1) | Box score |
| March 17, 2018 | * | Houston, Texas | Texas Southern 4, Prairie View A&M 2 | 5-13 | (3-1) | Box score |
| March 16, 2018 | * | Houston, Texas | Texas Southern 4, Prairie View A&M 1 | 4-13 | (2-1) | Box score |
| March 14, 2018 | Norman, Okla. | Oklahoma 10, Texas Southern 1 | 3-13 | Box score | ||
| March 13, 2018 | Norman, Okla. | Oklahoma 12, Texas Southern 0 | 3-12 | Box score | ||
| March 11, 2018 | * | Baton Rouge, La. | Texas Southern at Southern (Rained out) | |||
| March 10, 2018 | * | Baton Rouge, La. | Texas Southern 8, Southern 1 | 3-11 | (1-1) | Box score |
| March 9, 2018 | * | Baton Rouge, La. | Southern 9, Texas Southern 8 | 2-11 | (0-1) | Box score |
| March 6, 2018 | Nacogdoches, Texas | Stephen F. Austin 9, Texas Southern 4 | 2-10 | Box score | ||
| March 4, 2018 | Lawrence, Kan. | Kansas 7, Texas Southern 1 | 2-9 | Box score | ||
| March 3, 2018 | Lawrence, Kan. | Kansas 3, Texas Southern 2 | 2-8 | Box score | ||
| March 2, 2018 | Lawrence, Kan. | Kansas 7, Texas Southern 5 | 2-7 | Box score | ||
| Feb. 27, 2018 | Houston, Texas | Houston 4, Texas Southern 3 | 2-6 | Box score | ||
| Feb. 25, 2018 | Abilene, Texas | Abilene Christian 8, Texas Southern 1 | 2-5 | Box score | ||
| Feb. 24, 2018 | Abilene, Texas | Texas Southern 8, Abilene Christian 6 | 2-4 | Box score | ||
| Feb. 24, 2018 | Abilene, Texas | Abilene Christian 6, Texas Southern 5 | 1-4 | Box score | ||
| Feb. 20, 2018 | Houston, Texas | Houston Baptist 15, Texas Southern 3 | 1-3 | Box score | ||
| Feb. 18, 2018 | % | Beaumont, Texas | Texas Southern 4, Lamar 3 | 1-2 | Box score | |
| Feb. 18, 2018 | % | Beaumont, Texas | Missouri State 6, Texas Southern 5 | 0-2 | Box score | |
| Feb. 16, 2018 | % | Beaumont, Texas | Missouri State 8, Texas Southern 2 | 0-1 | Box score |
|
Home games in bold
* = Southwestern Athletic Conference game % = Cardinal Classic (Beaumont, Texas) |